Postdoctoral Associate - Molecular & Cellular Biology - Xi Chen (90007701)
· Baylor College of Medicine
· Location: Houston, TX
· Job Number: 7067989 (Ref #: 4221-en_US)
· Posting Date: Jul 17, 2020
· Application Deadline: Open Until Filled
A Postdoctoral position is available in the laboratory of Dr. Xi Chen, Assistant Professor and CPRIT scholar in cancer research at the Department of Molecular and Cellular Biology, Lester and Sue Smith Breast Center and NCI designated Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine. The Chen lab studies the function and mechanism of Endoplasmic Reticulum (ER) protein quality control machinery in cancer progression, metastasis and therapy resistance, with special focus on cancer immunotherapy. Our long-term goals is to elucidate the significance and mechanisms of ER proteostasis in cancer progression, metastasis and therapy resistance, and developing mechanism-based novel therapies to overcome therapy resistance and transform cancer to a manageable chronic disease. Our recent study revealed an unprecedented role of the IRE1a/XBP1 branch of the UPR in mediating tumor homeostasis and therapy resistance. We have developed a mechanism-based combination therapy with the IRE1a RNase inhibitor and docetaxel that completely eradicated the primary patient-derived breast tumors, prevented recurrence and triggered robust immune response. This study has led to an clinical trial. The highly interdisciplinary and collaborative environment of our group provides unique career development opportunities for the postdoc trainees. Please refer to our representative independent and collaborative publications for details: [Nature: 508(7494):103-7; Cell: 133:1106-17; JCI, 128 (4): 1283-1299; Nature Immunology: 11(5):411-8; Nature Cell Biology: 13(1):59-65; Nature Immunology: 12(1):96-104; Cancer Cell: 24(3):347-64; Nature Genetics: 38: 431-40; Genes Dev: 21: 2545-57].
· Plans, directs and conducts specialized and advanced research experiments.
· Evaluates and analyzes data.
· May establish new research protocols and procedures。
· Summarizes research findings and publish results in research journals.
· May be responsible for laboratory operations.
· May supervise research staff.
· Ph.D. (or equivalent) in biomedical sciences, highly motivated and career-oriented.
· Strong background and working knowledge in immunology and cancer biology。
· Expertise in animal models and flow cytometry is strongly preferred.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer。
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.